To unfavorite legendary runes, go to your rune inventory and locate the legendary runes you want to remove from favorites. Then, click on the favorite button or star icon associated with each rune to deselect it as a favorite. Follow My Health Sharp
You have to crush legendary gems.
Someone will have to tell you where, and how many you need, unless you can find it in the game somewhere, ie where it is done, or in the forum data base .
I just checked myself, as I thought I had recently come across it.
Workshop, and it was 2 for Topaz, which appears first in my list.